Alton Hickey

  • Alton Hickey posted an update 2 days ago

    Conflict of interestAcknowledgementsIntroductionCoenurosis is a parasitic disease caused by the metacestode stage of Taenia multiceps (Cestoda, Taeniidae) commonly known as Coenurus cerebralis (Rostami et al., 2013). The adult tapeworm inhabits the small intestine of a number of domestic and wild carnivores, including dogs, jackals, foxes and…[Read more]

  • In the field, it has been observed that prior exposure of the sow herd to PEDV ameliorates the impact of PEDV infection in neonates, presumably via maternal immune mechanisms (Goede and Morrison, 2016). Based on these observations, it has been postulated that PEDV-specific IgG and IgA in colostrum and milk are critical for the protection of…[Read more]

  • By analyzing the p22 amino bombesin receptor sequence, we found a putative zinc finger domain in the N-terminal part of the molecule as described for the CTV p23 suppressor (López et al., 2000). Interestingly, although CTV p23 has no homologs in other closteroviruses (Lu et al., 2004), it contains a zinc-finger motif that is almost identical to…[Read more]

  • Based on molecular phylogenetic studies of the mitochondrial cox1 gene of various spirurid nematodes, D. immitis and S. lupi are related genetically, and have 91% homology (Traversa et al., 2007). The commercial in-clinic serological tests for detecting D. immitis cycloastragenol were not evaluated for cross-reactions with S. lupi nematodes. The…[Read more]

  • Alton Hickey posted an update 5 days ago

    CAV1 is the major integral membrane protein in the caveolae, which are cup-shaped invaginations of the cell surface, and it is essential for their formation in non-muscle Neuronal Signaling Library (Alexander et al., 2013). Caveolae have been shown to serve as vehicles for the invasion of many viruses into animal cells (Bousarghin et al., 2003;…[Read more]

  • IntroductionHuman action classification is an important research topic in the fields of computer vision and pattern recognition. It is a growing challenging problem and well worth studying in the task of automatically analyzing and interpreting video data in computer vision and image analysis. It is of significant use in many applications, such as…[Read more]

  • AcknowledgementsIntroductionAlveolar echinococcosis (AE), caused by infections with the larval (metacestode) stage of Echinococcus multilocularis, has been considered one of the most dangerous helminthic zoonoses in the northern hemisphere (Eckert et al., 2011). The estimated number of new AE cases in Western and Central Europe (including the…[Read more]

  • Although the MPC is defined as the MIC of the least susceptible first-step resistant mutant present in a bacterial population (Drlica, 2003), the MPCs were used in the present study as a prevention concentration of first-step mutation by a single-exposure to MAR in the present study to elucidate the phenotypic and molecular resistance in S.…[Read more]

  • A better understanding of the transmission of H7N9 IAV in live-animals markets is needed to help inform public health and minimize infections in humans (Bao et al., 2013). Although some early work has suggested an epidemiological link between human cases and chickens (Chen et al., 2013), additional species could play a more significant role in the…[Read more]

  • Author contributionsAcknowledgementsWe gratefully acknowledge Myriam Siffert (Institute of Pathology, Vetsuisse Faculty, University of Bern) and Vreni Balmer (Institute of Parasitology) for their excellent technical assistance. David Arranz Solís was supported by a fellowship from the Spanish Ministry of Economy and Competitiveness (MINECO), as…[Read more]

  • Mechanistically, IL-6/STAT3 signaling is constitutively activated in various types of cancers including prostate cancer, breast cancer, leukemia, multiple myeloma, brain tumors, and OSCC. Persistent oncogenic STAT3 activation is associated with poor prognosis of OSCC patients and promotes malignant progression. In addition, IL-6/STAT3 is an…[Read more]

  • DiscussionDespite the importance of Y. pseudotuberculosis as a pathogen and a zoonotic agent, literature on yersiniosis in animals is scarce and is restricted to case reports. The present study characterised the O-genotype, virulence determinants, and genetic relatedness of Y. pseudotuberculosis isolates collected from animals with yersiniosis,…[Read more]

  • Alton Hickey posted an update 2 weeks ago

    A puzzling aspect of protein VI relates to its copy number in the virus particle. Recent mass spectrometry analyses of HAdV using in depth quantitative proteomics demonstrated that virions contain ~360 copies of protein VI (Benevento et al., 2014). However the X-ray structure of HAdV revealed only a maximum of 180 copies of protein VI. One…[Read more]

  • Altogether, the FCoV genome encodes five accessory proteins termed 3a, 3b, 3c, 7a and 7b (Dye and Siddell, 2005; Tekes et al., 2008). Using a reverse genetics approach, Haijema et al. (2004) showed that the accessory genes of the FIPV strain 79-1146 are dispensable for viral growth in vitro and recombinant viruses that lack ORFs 3a–3c or 7a and 7…[Read more]

  • Materials and methodsResultsDiscussionAcknowledgementsIntroductionCastration avoids ‘boar taint’, caused by compounds such as androstenone and skatole, which give the meat an offensive odour. However, castration is one of the most controversial management practices in swine production, because it is usually performed without the use of per…[Read more]

  • Conflicts of interestAuthor contributionsDisclaimerFootnotesThis work was funded by the NIAID, NIH grant AI102725 (to VBR) and in part by F32AI115912 (to ELM) and HJF subaward W81XWH-11-2-0174 (to VBR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of…[Read more]

  • In 2014, we discovered a novel CoV named dromedary camel CoV UAE-HKU23 (DcCoV UAE-HKU23); the complete genome of this virus was sequenced directly from dromedary faecal samples and its phylogenetic relationship with other CoVs was determined (Table 1) (Wernery et al., 2014). We speculate that the bovine CoV-like CoV, with limited sequence i…[Read more]

  • Our study, for the first time, revealed localization of Ki67- or LGR5-positive crypt calcium channel blockers in the small intestine of nursing and weaned pigs, with or without PEDV infection. Intestinal stem cells located in the villous crypts replace the apoptotic (normal process) or necrotic (virus-induced) enterocytes shed at the villous tips…[Read more]

  • Alton Hickey posted an update 4 weeks ago

    ConclusionsAcknowledgementsThis research was supported in part by National Institutes of Health (Grant AI109569).IntroductionHuman papillomaviruses (HPVs) constitute a family of more than 100 viruses, which infect the mucosa and the squamous epithelia (Bernard et al., 2010). HPVs are classified as Low Risk or High Risk depending on their…[Read more]

  • Effective host defense against pulmonary bacterial infections depends on the rapid clearance of bacteria from the respiratory tract (Bosse et al., 2002). Complement evasion is one of the mechanisms by which pathogenic bacteria evade attack by the host monocarboxylate transporters (Nakamura et al., 2011). A. pleuropneumoniae strains were found to…[Read more]

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